TH and neuroblastoma: We used human neuroblastoma SH-SY5Y cell line, because these cells are able to express a number of features characteristic for catecholaminergic neurons, including tyrosine hydroxylase and dopamine-β-hydroxylase activities [21], as well as express various P2 receptors belonging to both P2X and P2Y families [22], including active P2X7R [11].