Based on ROC curve analysis, the specificity/sensitivity for PCa in tissue samples was 90%/90% for DOCK2, 84%/100% for HAPLN3, and 100%/95% for FBXO30, with corresponding AUCs of 0.970, 0.992, and 0.972, respectively (Figure 3G–I). Here, HAPLN3 is linked to posterior cortical atrophy.