Furthermore, we demonstrated that p22 can increase TCF/β-catenin transcription on its own and in conjunction with ectopically expressed wild-type or mutant β-catenin; and in colon cancer cells with endogenous mutant APC (SW480 cells) or CTNNB1 (HCT116 cells). Here, CTNNB1 is linked to malignant colon neoplasm.