An upregulation of TNFα is linked to increased leukocyte infiltration and tumor formation and is usually detected in colorectal neoplasms, and in animal models of CRC [208,209] and IL-6 is highly upregulated in many cancers and is considered as one of the most important proinflammatory cytokines during carcinogenesis and metastasis [48]. This evidence concerns the gene IL6 and cancer.