Falcarindiol appears to be an effective inhibitor of COX-2 in vitro, as demonstrated in colon cancer and colon epithelial cells [141,189] and in LPS-stimulated RAW 264.7 macrophage cells [163], as well as a an effective COX-1 inhibitor [190,191,192], where an IC50 value of 0.3 μM has been reported [190]. This evidence concerns the gene PTGS2 and colonic neoplasm.