COX-2 overexpression but not COX-1 has been detected in 50% of colorectal adenomas and in up to 85% of colorectal carcinomas, and it is correlated with poor prognosis, and therefore COX-2 is considered as one of the most important drug targets for the prevention of CRC [39]. The gene discussed is PTGS2; the disease is colorectal carcinoma.