TNF-α produced during chronic inflammation appears to enhance tumor development and dissemination as it is a major cytokine in the tumor microenvironment, being capable of regulating other proinflammatory cytokines and hence is able to influence several of the hallmarks of cancer, including stimulation of tumor-cell growth, survival, invasion, metastasis, and neoangiogenesis [46,47]. The gene discussed is TNF; the disease is neoplasm.