Such higher survivability and neuronal differentiation of F3.ChAT cells than F3 parental cells were also confirmed in other AD animal models [6,7], which may be due to the increased production of neuroprotective and anti-inflammatory GFs/NFs including VEGF, GDNF, NGF, and CNTF in F3.ChAT cells [10]. This evidence concerns the gene GDNF and Alzheimer disease.