Although the mechanisms by which these 11 lncRNAs are involved in tamoxifen resistance and systemic relapse are unclear, several relapse- or metastasis-related pathways, such as the PI3K/AKT and Wnt signaling pathways, are upregulated in patients with breast cancer who have a high relapse risk predicted by the expression levels of these lncRNAs. The gene discussed is AKT1; the disease is breast cancer.