CA4 and neoplasm: In another study, combination of CA-4 and doxorubicin was used for new polymeric micelle (PM) system development based on a ligand of integrins, cyclic arginine-glycine-aspartic acid-tyrosine-lysine pentapeptide (cRGDyK) was conjugated to the polyethylene glycol (PEG)-b-poly lactic acid (PEG-b-PLA) copolymers physically encapsulated with the antivascular agent CA-4 and chemically linked with the cytotoxic agent doxorubicin for treatment of tumor neovasculature.