Compared to optimal, blood chemistry profiles (i.e., FBG, insulin, HOMA-IR, TC, HDL-C, TG, AST and ALT) also became worse in the order of sarcopenia, obesity and sarcopenic obesity, in the lower, middle and upper eCRF categories (refer to Tables S1–S3 in the Supplementary Materials). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.