Recently, Guo and colleagues described a stronger expression of PD-L1 expression in EGFR mutant NSCLC cells in comparison to non-mutant EGFR NSCLC, which was associated with increased expression levels of phospho-IκBα and hypoxia-induced factor 1α (HIF-1α) [43]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.