Since the overall expression of HTRA1 was found to be increased in tumor tissue (Figure 1A), we compared mRNA level of the gene in control mucosa with the mRNA levels in the MSS and MSI tumors, and found that the HTRA1 transcript level was significantly higher in the MSS tumors than in the control tissue (p < 0.01). This evidence concerns the gene HTRA1 and neoplasm.