More recently, a study performed among 354 Mayo Clinic patients with NAFLD-cirrhosis, showed that diabetes (HR: 4.2, 95% CI 1.2–14.2, p = 0.02), age and low albumin significantly predicted the development of HCC, whereas other metabolic risk factors, such as increased Body Mass Index (BMI), hyperlipidemia and hypertension, did not [44]. The gene discussed is ALB; the disease is metabolic dysfunction-associated steatotic liver disease.