More recently, Grimaudo et al. performed a prospective study on 471 patients with histologically proven NAFLD which demonstrated an independent association between PNPLA3 C > G variant and HCC (HR: 2.10, 95%CI: 1.03–4.29; p = 0.04 [59]. This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.