PEDV infection was significantly enhanced in cells treated with supernatant from wild-type nsp15 and D265A mutant transfected cells than that from mutant H226A, H241A, K282A or empty vector transfected cells (Figure 6C), confirming that PEDV nsp15 can evade the host antiviral response by antagonizing IFN production. Here, IFNA1 is linked to infection.