Both these proteins function as cell cycle regulators and are considered as important tumor suppressors; p14 ARF is involved in stabilization of p53 by downregulating MDM2 mediated p53 ubiquitination [77], while p16INK4a is a cyclin-dependent kinase (CDK) inhibitor involved in the retinoblastoma (pRb) pathway [78]. This evidence concerns the gene CDKN2A and neoplasm.