LGALS1 and cancer: Based on previous studies suggesting that activated MAPK JNK/p38 signaling pathway could contribute to EMT in malignant tumors [83], Zhu et al. [56] assessed whether this pathway was involved in the regulation of EMT by Gal-1 in their siRNA Gal-1 knocked down SKOV3ip cells and Gal-1 overexpressing SKOV3 cells.