CPT2 and hepatocellular carcinoma: Fujiwara et al. suggested that this is plausible because, in the diethylnitrosamine (DEN)-induced HCC model, high fat diet (HFD)-fed mice showed an up-regulation of CPT1A, which converts FA-derived acyl-CoA to Acylcarnitine, while CPT2 (which reconverts acylcarnitine to AcylCoA) results in down-regulated CPT2 [107].