Acetylcholinesterase inhibitors (AChEI) such as donepezil, rivastigmine, and galantamine, able to increase the level of biogenic amines in the brain, or memantine, a non-competitive antagonist of the N-Methyl-D-Aspartate (NMDA) receptor, are the only drugs currently administered to AD patients [6]. The gene discussed is ACHE; the disease is Alzheimer disease.