KRAS and gastric cancer: To test whether KRAS affects CCNA2 expression or vice versa, KRAS mutant gastric cancer cell lines were transfected with siRNAs targeting KRAS or CCNA2. Therein, the KRAS mutant gastric cancer cell lines (AGS, SK4 and SNU601) showed decreased CCNA2 expression after depletion of mutant KRAS, whereas CCNA2 knockdown did not affect expression of KRAS (Figure 4c).