In MKN28 and other sensitive cancer cell lines (AGS and SNU601), but not in SNU719 cells, BI-2536 elicited PARP1 cleavage, JNK phosphorylation and caspase-3 cleavage, all of which are indicative of apoptosis induction (Figure 2c and Figure S2a). The gene discussed is MAPK8; the disease is cancer.