CCNA2 and cancer: Control cells showed marked cell cycle arrest at the G2/M-phase at 24 h posttreatment with BI-2536; however, shCCNA2 cells slipped over from the G2/M-arrest and showed accumulation of polyploidy at 48 h and 72 h post BI-2536-treatment in a dose-dependent manner (Figure 3b), indicating that cancer cells characterized by high expression of cyclin A2 undergo less mitotic slippage and more apoptosis in response to BI-2536 treatment than cyclin A2 knockdown cells.