For instance, among the UCHs or ubiquitin carboxy-terminal hydrolases, a subfamily member of DUBs, BAP1 (BRCA1-associated protein 1) possesses unique ability as a tumor suppressor, while others (UCH-L1, UCH-L3, UCH-L5) are characterized as tumor promoters [2,3,4,5,6]. Here, UCHL5 is linked to neoplasm.