Conversely, the improvement of periodontal status and the healing of periodontal tissues after therapy have been shown to reduce the systemic levels of inflammatory markers [48,50,51,52,53] such as CRP, E-selectin and TNF- α, and also to help in the control of systemic conditions such as hyperglycemia [50,52], AMI and stroke [40] and endothelial dysfunction [48]. The gene discussed is TNF; the disease is Hyperglycemia.