It has been observed that iNKT cells from allergic asthma (AA) patients expressed higher levels of the activating NK receptors NKp30 and NKp46, perforin, and granzyme B, and iNKT cell cytotoxic phenotype positively correlated with disease severity, as granzyme B expression was significantly increased in patients suffering from severe to moderate AA compared to healthy individuals [82]. The gene discussed is GZMB; the disease is allergic asthma.