While chemotherapy induced iNKT cell cytotoxicity in vitro through the expression of TRAIL and Fas ligand [91], human colon cancer cells treated with thymosin α1 (an immune adjuvant) and α-GalCer were eliminated by peripheral blood iNKT cells through granzyme B and perforin release, and the same treatment also reduced tumor growth in NOD-SCID mice [105]. Here, PRF1 is linked to neoplasm.