These findings were recently corroborated by experiments in which renin-angiotensin system inhibitors were administered after weaning: losartan eliminated inflammatory infiltration and intrarenal renin-angiotensin system (RAS) activation [43] while transient exposure to enalapril reduced glomerular filtration rate (GFR) and prevented the onset of hypertension [44]. This evidence concerns the gene REN and hypertensive disorder.