Of the 10 Fzd receptors, Fzd2, 5, 7, 8, and 9 have been shown to be upregulated in GC tissue [51], with recent evidence from our group that Fzd7 is important in transmitting Wnt signaling in gastric tumors to drive tumor initiation and growth [31]. The gene discussed is FZD7; the disease is neoplasm.