More so, the stem cell marker LGR5 was found to promote proliferation, invasion, and migration of GC cells through the regulation of canonical Wnt signaling [69] as GC cells treated with the porcupine inhibitor (C-59) dampened LGR5-induced proliferation and migration of GC cells, whereas Wnt3a-treated cells rescued the LGR5-induced phenotype. This evidence concerns the gene LGR5 and gastric cancer.