Cytogenetic testing (karyotype) and Y chromosome microdeletion analysis are recommended in patients with azoospermia and severe oligozoospermia (<10 million sperm/ejaculate) due to primary testicular failure (generally, normal semen volume and pH, testicular hypotrophy and normal/high FSH) [1,22,23,24,25,26]. This evidence concerns the gene BRD2 and Azoospermia.