The products of these genes are also reported to be involved in various diseases such as cancers, inflammatory bowel disease, Alzheimer’s disease, and chronic kidney disease, and in various biological functions such as apoptosis, endoplasmic reticulum stress, osmotic stress, nuclear factor-kappa B (NF-κB), mammalian target of rapamycin (mTOR), and Notch signaling. The gene discussed is NFKB1; the disease is cancer.