FATE1 is most robustly induced by the Ewing sarcoma breakpoint region 1-Friend Leukemia Integration 1 (EWSR1-FLI1) chimeric transcription factor caused by a pathognomonic chromosomal translocation of Ewing sarcoma and interacts with Bcl-2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L). The gene discussed is FATE1; the disease is Ewing sarcoma.