Hypoxia stimulates the interaction of vIIIEGFR with the integrin β3 in GBM cells, activating a signalling pathways c-SRC-dependent resulting in the up-regulation of the cancer cell invasion markers, like matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) [12]. Here, MMP2 is linked to cancer.