ADRB3 and neoplasm: In addition to several studies on melanoma, discussed below, we recently demonstrated that β3-AR is expressed in both murine and human neuroblastoma (NB) cell lines, and in tumor biopsies from NB patients; in this study, pharmacological antagonism of β3-AR, in a murine syngeneic model of NB, was able to reduce tumor growth by affecting the neuronal differentiation of NB cancer cells [85].