In the same study, thorough a murine syngeneic experimental model (B16-F10 inoculated in C57BL mice), β3-AR antagonists SR59230A and L-748,377, were both able to significantly reduce melanoma growth in vivo, in comparison with propranolol, by reducing cell proliferation and inducing apoptosis of cancer cells. Here, ADRB3 is linked to melanoma.