Anyhow, animal models showed an unfavorable association with cardiovascular risk factors [25,26] Although the role of SCD-1 in humans is not completely understood, several studies reported its unfavorable association with cardiometabolic profile, in particular with BP [27], obesity [28] and insulin sensitivity [29], even in children [30]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.