VEGFA and metastatic melanoma: Moreover, the inhibiting effect of both SFN and FB on the production of the pro-angiogenic factor VEGF demonstrated in metastatic melanoma cells is in agreement with what was previously observed by using SFN alone in other cancer cell models in vitro, including colon [45], prostate [46,47], tongue squamous [47] cancer cells, as well as leukemia [48] and hepatocellular carcinoma cells [49].