Since we showed a greater inhibitory effect of the FB/SFN combination on cell migration in the metastatic WM266-4 cell line, we evaluated if SFN and FB could alter the production of collagenase MMP-1, gelatinases MMP-2 and MMP-9 and stromelysin MMP-3 in this melanoma cell line (Figure 4). This evidence concerns the gene MMP1 and melanoma.