c-Myc inhibition by treatment with 10058-F4 or transduction of c-Myc by c-Myc/shRNA in human macrophages stimulated by tumor-conditioned medium from PANC-1 (human pancreatic cancer cell line) suppresses expression of protumoral genes (ALOX15, CD206, TGF-β, VEGF, HIF-1α and MMP9) [21] (Table 1). Here, HIF1A is linked to neoplasm.