In the tumor microenvironment, TAM-derived IL-10 inhibits IL-12 production associated with the lack of NF-κB activation promoting tumor survival, while blocking of IL-10 restores the IL-12 production in a mouse model of fibrosarcoma [85] Tumor-promoting activation of NF-κB in macrophages was also demonstrated [46]. The gene discussed is IL10; the disease is fibrosarcoma.