The recent study in mature murine BMDMs cultured in conditioned medium of Hepa1-6 (murine hepatoma cells) demonstrated that Wnt/β-catenin signaling mediates polarization of M2 macrophages through activation of c-Myc that supports the progression of hepatocellular carcinoma (HCC) [22]. The gene discussed is MYC; the disease is hepatocellular carcinoma.