In LLC mouse model, TAMs isolated out of tumor expressed significantly increased levels of hypoxic factors including VEGFR, Slc2a1, PDK1, and C-X-C motif chemokine receptor-4 (CXCR4), M1-polarized marker (NOS-2) as well as M2-polarized marker (ARG1), and immunosuppressive cytokines such as TNFa and IL-10. The gene discussed is CXCR4; the disease is neoplasm.