TNF and neoplasm: TAMs polarized to immunosuppressive phenotype with high expression of IL-10, TNF-α, and ARG1, but low expression of NOS2, IL-12, and MHC II, that was mediated by the IL-1R and MyD88 via NF-κB activation, resulted in increased tumor invasiveness and tumor growth in ovarian cancer in vitro and in vivo [46].