TLR9 and neoplasm: Additionally, in vivo delivery of CpG oligodeoxynucleotide, a Toll-like receptor 9 agonist, to tumor-bearing mice with pancreatic ductal adenocarcinoma (PDAC) cells resulted in the suppression of tumor growth in pancreatic cancer models enhancing the anti-tumor activity of F4/80+ TAMs through the induction of phagocytosis of tumor cells [243].