NLRP3 and cancer: The uncontrolled formation of NLRP3, arising from different cellular challenges such as presentation of lipopolysaccharides, viruses, or abnormal ion fluxes, induced IL-1β and IL-18 productions, resulting in development of various cancer types, including head-and-neck squamous cell carcinoma [75], oral squamous cell carcinoma [76], and breast cancer [77].