ADIPOQ and malignant colon neoplasm: In vitro experiments, adiponectin inhibits colon cancer cell growth in adiponectin receptor (AdipoR1- and -R2) positive HCT116, HT29, and LoVo cells through the AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling pathway [71,72].