SIRT1 and familial dilated cardiomyopathy: However, though signal transduction pathways such as ERK1/2/Homer1a/SIRT1, AMPK/SIRT1, SERCA2a/UPR/SIRT1, FOXO3a/SIRT1, NF-κB/SIRT1, eNOS/SIRT1 play crucial role in the pathophysiology of DCM, the exact pathomechanism of the disease has not been elucidated [28].