For example, halistanol trisulphate (29) (Figure 6), a C-29 steroidal detergent isolated from the Indo-Pacific sponge Haliclona sp., was shown to inhibit the maturation of tyrosinase to a form that is associated with melanin synthesis in the pigmented human melanoma cell line, MM418 [180]. The gene discussed is TYR; the disease is melanoma.