Surh et al. also demonstrated that tetrahydrocurcumin had a weaker inhibitory effect on the DNA binding activity of transcription factors, NF-κB, and signal transducer and activator of transcription 3 (STAT3) and downstream inflammatory enzymes, and consequently showed a weaker inhibitory effect than curcumin on dextran sulfate sodium (DSS)-induced mouse colitis [68]. The gene discussed is STAT3; the disease is colitis.