Hyper-activated STAT3 regulates the expression of interferon γ (IFNγ), interleukin 12 (IL-12), CD86, C-C motif chemokine ligand 5 (CCL5), and C-X-C motif chemokine ligand 10 (CXCL10) in the tumor microenvironment to promote immune evasion [12,13]. This evidence concerns the gene STAT3 and neoplasm.