The number of BOSCC negative for profilaggrin was higher than with all other antibodies, since profilaggrin and filaggrin are markers that are expressed later in the differentiation process, responsible to the keratin aggregation, have a short life span, and cannot be detectable in hyperproliferative lesions, either benign or malignant [29], which may be due to the type of keratinisation in these tumours. Here, FLG is linked to neoplasm.