It was revealed that both Phidianidines exhibit in vitro cytotoxic activity against tumor and non-tumor mammalian cell lines (rat glial—C6, human cervical—HeLa, colon adenocarcinoma—CaCo-2, mouse embryo—3T3-L1 and rat heart myoblast—H9c2) as well as selective agonist properties against protein-tyrosine phosphatase 1B (PTP1B) and chemokine receptor type 4 (CXCR4) [26,27]. Here, CXCR4 is linked to neoplasm.