Figure 7D is the average fractional change over 8 h for three subjects with varying levels of baseline CFTR function (non-CF = normal function; F508del/P67L = residual function; and F508del/F508del=minimal function). In Figure 7E, the fractional change for each subject is shown, showing significant distinctions for the CFTR function between all three subjects at 8 h while not at 1 h. The gene discussed is CFTR; the disease is cystic fibrosis.