Thus, in addition to the effectiveness of the combination of α-GalCer and CpG-ODN adjuvants, our results presented here highlight the importance of the intranasal route of vaccination for increasing antigen-specific CD8 T cell immune responses in the vaginal mucosa for significantly enhancing antitumor efficacy and therapeutic outcome in the genital HPV tumor preclinical model. Here, CD8A is linked to neoplasm.