NEDD4L and myocardial infarction: Finally, us and other authors [63,64], have previously found that Nedd4-2 C2 KO mice showed eplerenone-resistant salt-sensitive hypertension [65] and enhanced electrophysiological abnormalities, after myocardial infarction [66], suggesting a pivotal role of the Nedd4-2 isoform with C2 domain for cardio-renal association, with regards to target-organ damages of the subjects with salt-sensitive hypertension.