Other experiments were performed including the discovery of a rodent NEDD4L gene C2 domain expressed along urinary tubules [59], heterologous gene expression in the Xenopus oocytes experiments with dominant negative effects of newly discovered human isoform I [60], the discovery of the NPC2 protein as a C2 domain binding protein in urinary tubules [61], and a genetic association study for human hypertension [53,54,55]. The gene discussed is NEDD4L; the disease is hypertensive disorder.