For example, mutations within the 20YXXΦ23 motif (endocytic signal) [162] that targets IFITM3 to endosomes led to its accumulation at the plasma membrane and restored infection by viruses that enter cells by endocytosis, such as IAV or human coronaviruses NL63 and 229E [162,163,164,165]. The gene discussed is IFITM3; the disease is infection.