Again, the data showed significantly higher luciferase gene (carried by the CML cells) expression in the SC-targeted CRISPR/Cas9 virus-treated mice than in the ABL-targeted CRISPR/Cas9 virus-treated mice, indicating a strong therapeutic effect of ABL-targeted gene therapy in a systemic animal model of human leukemia. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.