Likewise, the other two DEGs identified in the present study—PPARGC1A (peroxisome proliferator-activated receptor-γ co-activator-1alpha) and PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor)—have been associated with obesity in humans. This evidence concerns the gene PCSK1 and obesity due to melanocortin 4 receptor deficiency.