At baseline, a significantly higher Gal-3 concentration was observed in the group of patients with atherosclerotic plaques in carotid arteries vs. patients without carotid atherosclerosis (14.7 ± 7.2 ng/mL vs. 10.5 ± 4.1 ng/mL, p = 0.00001). This evidence concerns the gene LGALS3 and carotid atherosclerosis.