For example, the EDGE study (Effectiveness of Diabetes control with vildaGliptin and vildagliptin/mEtformin) revealed that 12 weeks of sitagliptin treatment increased circulating CD34+ cells (p = 0.03) but did not change inflammatory markers (i.e., high-sensitivity CRP and pentraxin-3) and oxidative stress markers (i.e., malondialdehyde-modified low-density lipoprotein and urine 8-hydroxy-2′-deoxyguanosine) [169]. This evidence concerns the gene CD34 and diabetes mellitus.