Moreover, the downregulation of insulin-like growth factor 1, insulin-like growth factor-binding protein 5, osteoprotegerin, and vascular endothelial growth factor (VEGF) n the BM plasma of T1DM mice was associated with reduced Bmi1expression, a gene involved in senescence protection, and with an impaired HSPC repopulation of BM [108]. The gene discussed is VEGFA; the disease is type 1 diabetes mellitus.