PNPLA3 and metabolic dysfunction-associated steatotic liver disease: To date, at least five variants in different genes have been found to be strongly associated with the susceptibility to and progression of NAFLD, namely, PNPLA3, transmembrane 6 superfamily member 2 (TM6SF2), glucokinase regulator (GCKR), membrane bound O-acyltransferase domain-containing 7 (MBOAT7), and hydroxysteroid 17β-dehydrogenase (HSD17B13) [10].