PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Compared to western populations, Asians are particularly susceptible to NAFLD partially because of body composition differences in fat and muscle, as well as genetic susceptibility through the predisposition to T2DM, patatin-like phospholipase domain containing 3 (PNPLA3) SNPs, and polymorphisms in apolipoprotein 3 [3].