SIRT1 and Obesity: Another interesting example is the one offered by the study of Choi et al. [153] in which they not only show the participation of CK2 in inflammatory pathologies, such as obesity and NAFLD, but also identify the obesity-linked Ser-164 phosphorylation of SIRT1 by CK2 as the main responsible mechanism for inhibiting the nuclear localization of SIRT1 and for affecting, to some extent, its enzymatic activity.