Moreover, Purushotam et al. [32] observed that mice with a specific deletion of Sirt1 gene in hepatocytes resulted in animals presenting a damaged β-oxidation due to an impaired PPAR-α/PGC1-α pathway, developing liver steatosis, inflammation and endoplasmic reticulum stress when fed with a high fat diet. Here, SIRT1 is linked to Hepatic steatosis.