NFKB1 and liver disorder: Given that the burden of liver pathologies throughout the world supposes numerous deaths every year and that, until now, there is no effective cure for many of these pathologies, whose common feature is usually the presence of inflammation to a greater or lesser extent, approaches attempting to target the mechanisms that modulate inflammation, such as the SIRT1-NF-κB axis, could represent a major breakthrough in the treatment of liver disease.