Another fact to keep in mind when talking about modulation of SIRT1 as anti-inflammatory therapy for the treatment of liver diseases, specially metabolic ones, is the anti-oxidant properties attributed to SIRT1 and other sirtuins (through deacetylation of transcription factors, such as FOXO family or PGC-1α, with capacity to induce expression of numerous anti-oxidant enzymes) [175]. The gene discussed is SIRT1; the disease is liver disorder.