In relation to this, it is necessary to highlight that several upstream regulators of SIRT1 have been described, including IRF9, PPAR-α, NAMPT, NMNAT, HuR, AMPK, PPAR1, CK2 and cathepsins, which are able to regulate inflammation through SIRT1 modulation and that, as a consequence, have been involved in different inflammatory disorders, including hepatic diseases. The gene discussed is PPARA; the disease is liver disorder.