A large body of evidence suggests that SIRT1 plays a major role in various diseases, such as rheumatoid arthritis (Li et al. 2018), atherosclerosis (Sosnowska et al. 2017), insulin sensitivity (Hui et al. 2017) and kidney disease (He et al. 2010, Hasegawa et al. 2010). The gene discussed is INS; the disease is atherosclerosis.