A previous report focused on the optic atrophy defect (Bertacchi et al, 2019), an important component of the clinical phenotype (Bosch et al, 2014; Chen et al, 2016), but nothing was known on whether NR2F1 haploinsufficiency would lead to particular types of cortical malformations. This evidence concerns the gene NR2F1 and hereditary optic atrophy.