APC and colorectal carcinoma: The effects of MPA on cell‐cycle progression were not ascribed to cellular context as similar results were observed in a number of CRC cell lines, including RKO, LoVo, and LS174, harboring oncogenic alterations in K‐Ras, and/or B‐Raf, and mutations in the APC‐Wnt‐ß‐catenin pathway leading to c‐Myc upregulation (TCGA, 2012), but all having a functional p53 (Fig 4B and Appendix Fig S4D).